Absence of Hyperplasia in Gasp-1 Overexpressing Mice is Dependent on Myostatin Up-Regulation
Background/Aims: Overexpression of Gasp-1, an inhibitor of myostatin, leads to a hypermuscular phenotype due to hypertrophy rather than hyperplasia in mice.However to date, the cellular and molecular mechanisms underlying this phenotype are not investigated.Methods: Skeletal muscles of overexpressing Gasp-1 mice, called Tg(Gasp-1) mice, were analyz